Quite often, bioinformatics analyses take ages to run. This makes it difficult if you are running thing on the command-line and want to shut down your computer without the program being terminated. Luckily there are a few solutions to this, the one I have been using recently is called screen. This program allows you to open a "screen session" on your terminal, run software and most importantly, detatch it from the terminal. You can then re-attach it on a different terminal later. Here are a few pointers to get you going.